Trifluoroacetic acid → HCID 178511287, compound
Reaction equation
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([CH2:8][NH:9]C(=O)OC(C)(C)C)[CH2:4][CH2:3]1.FC(F)(F)C(O)=O>ClCCl>[NH2:9][CH2:8][C@H:5]1[CH2:6][CH2:7][C@H:2]([OH:1])[CH2:3][CH2:4]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Tert-butyl trans-(4-hydroxycyclohexyl)methylcarbamate (1 g) in dichloromethane (10 ml) was treated with trifluoroacetic acid (10 ml) at 0° C. for two hours. The reaction mixture was concentrated and the residue was dried under vacuum to provide the title compound.
Workup
- concentrationThe reaction mixture was concentrated
- customthe residue was dried under vacuum
Sources & evidence
- ORD record
- ord-5cb47aa7ef8144958e6711f8362b81b5
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09303025B2
Reaction notes
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