3-Bromo-4-chloropyridine → 5-Bromo-4-chloropyridine-3-carbaldehyde

HRID 626724Notes

Reaction equation

HRID 626724 reaction equation
[Cl:1][C:2]1[C:7](Cl)=[CH:6][N:5]=[CH:4][C:3]=1[CH:9]=[O:10].[Br:11]C1C=NC=CC=1Cl>CN(C=O)C>[Br:11][C:7]1[C:2]([Cl:1])=[C:3]([CH:9]=[O:10])[CH:4]=[N:5][CH:6]=1

Participants

4

Reactant 2

HCID 8176963-Bromo-4-chloropyridineHCID 595965804,5-Dichloropyridine-3-carbaldehyde

Product 1

HCID 717423075-Bromo-4-chloropyridine-3-carbaldehydeYield 73%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following the procedure described for 4,5-dichloropyridine-3-carbaldehyde, 3-bromo-4-chloropyridine and DMF were reacted to afford the title compound as a white solid (3.74 g, 73% yield). 1H NMR (300 MHz, CDCl3): δ 10.48 (d, J=0.4 Hz, 1H), 8.95-8.92 (m, 2H).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6dc8ca6f55e846a2a23bc86ea847bcb5
Source dataset
uspto-grants-2016_04
Patent number
US09309240B2

Reaction notes

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