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(2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate → N-(allyloxy)-N-((3R,6S)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6-(((tert-butyldimethylsilyl)oxy)methyl)-1,2,3,6-tetrahydropyridin-3-yl)-2-nitrobenzenesulfonamide

HRID 627286
Notes
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Reaction equation

HRID 627286 reaction equation
[CH2:1]([O:4][N:5]([C@H:18]1[CH2:23][N:22](C(OC(C)(C)C)=O)[C@H:21]([CH2:31][O:32][Si:33]([C:36]([CH3:39])([CH3:38])[CH3:37])([CH3:35])[CH3:34])[C:20]([CH2:40][CH2:41][O:42][Si:43]([C:46]([CH3:49])([CH3:48])[CH3:47])([CH3:45])[CH3:44])=[CH:19]1)[S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-:17])=[O:16])(=[O:8])=[O:7])[CH:2]=[CH2:3]>C(Cl)Cl.C(=O)(O)[O-].[Na+].[Br-].[Zn+2].[Br-]>[CH2:1]([O:4][N:5]([C@@H:18]1[CH:19]=[C:20]([CH2:40][CH2:41][O:42][Si:43]([C:46]([CH3:49])([CH3:47])[CH3:48])([CH3:44])[CH3:45])[C@@H:21]([CH2:31][O:32][Si:33]([C:36]([CH3:39])([CH3:38])[CH3:37])([CH3:34])[CH3:35])[NH:22][CH2:23]1)[S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-:17])=[O:16])(=[O:8])=[O:7])[CH:2]=[CH2:3]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 1

HCID 131735303(2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate2×

Product 1

HCID 89852205N-(allyloxy)-N-((3R,6S)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6-(((tert-butyldimethylsilyl)oxy)methyl)-1,2,3,6-tetrahydropyridin-3-yl)-2-nitrobenzenesulfonamideYield 100%

Reagents, catalysts & solvents 3

HCID 10421208
Zinc bromide
Catalyst
2×
HCID 6344DichloromethaneSolvent2×
HCID 516892Sodium BicarbonateSolvent

Procedure

To a solution of (2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate (Intermediate 282, 7.5 g, 10.11 mmol) in DCM (100 mL) at room temperature was added zinc bromide (6.83 g, 30.32 mmol). The reaction mixture was stirred overnight at room temperature. Another equivalent of zinc bromide was added and the reaction mixture was stirred for another 24 hours. The reaction mixture was diluted with DCM and saturated sodium bicarbonate was added. The biphasic mixture was filtered through celite to remove the solids and the layers were separated. The organics were washed once with brine, dried over magnesium sulfate, filtered and concentrated to afford an orange oil (6.49 g, 100%).

Workup

  1. stirringthe reaction mixture was stirred for another 24 hours
  2. additionwas added
  3. filtrationThe biphasic mixture was filtered through celite
  4. customto remove the solids
  5. customthe layers were separated
  6. washThe organics were washed once with brine
  7. dry with materialdried over magnesium sulfate
  8. filtrationfiltered
  9. concentrationconcentrated

Sources & evidence

ORD record
ord-f28e393fa74744f59ccc576060ea8d97
Source dataset
uspto-grants-2016_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09309245B2

Reaction notes

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