Triphosgene → 1-Difluoromethoxy-3-isocyanato-2-methylbenzene
Reaction equation
[F:1][CH:2]([F:12])[O:3][C:4]1[C:5]([CH3:11])=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7].Cl[C:14](Cl)([O:16]C(=O)OC(Cl)(Cl)Cl)Cl>C1(C)C=CC=CC=1>[F:1][CH:2]([F:12])[O:3][C:4]1[CH:10]=[CH:9][CH:8]=[C:6]([N:7]=[C:14]=[O:16])[C:5]=1[CH3:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
At room temperature, to a mixture of 3-difluoromethoxy-2-methylaniline 6.4 g and toluene 100 ml was added triphosgene 5.48 g, and the resulting mixture was stirred with heating under reflux for one hour. The reaction mixture was concentrated under reduced pressure to give 1-difluoromethoxy-3-isocyanato-2-methylbenzene 7.36 g.
Workup
- temperaturewith heating
- temperatureunder reflux for one hour
- concentrationThe reaction mixture was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-a40e5c5869b2438e8bd5aa4155140b81
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09314023B2
Reaction notes
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