Ethyl Bromide → 2-(Ethylthio)nicotinic acid

HRID 62852

Reaction equation

[SH:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Br[CH2:12][CH3:13]>>[CH2:12]([S:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])[CH3:13]

Participants

Reactant 2

HCID 6332Ethyl Bromide

HCID 178524460HCID 178524460, compound

Product 1

HCID 5917342-(Ethylthio)nicotinic acidYield 80%

Procedure

2-Mercapto-nicotinic acid (2 g, 12.8 mmol) and bromoethane were reacted in the same manner as in Step A of Preparation Example 1 to obtain the title compound (1.9 g, 80%).

Sources & evidence

ORD record: ord-48dbbad7bf1e4960bdcd62288ff1b12f
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447044B2

Linked notes

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