Bromomethylcyclopropane → 2-Cyclopropylmethylsulfanyl-nicotinic acid

Reaction equation

[SH:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Br[CH2:12][CH:13]1[CH2:15][CH2:14]1>>[CH:13]1([CH2:12][S:1][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])[CH2:15][CH2:14]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 178524460HCID 178524460, compound

Product 1

HCID 435600492-Cyclopropylmethylsulfanyl-nicotinic acidYield 88%

Procedure

2-Mercapto-nicotinic acid (1 g, 6.4 mmol) and bromomethyl cyclopropane were reacted in the same manner as in Step A of Preparation Example 10 to obtain the title compound (1.19 g, 88%).

Sources & evidence

ORD record: ord-5ab7d3a4b66e4d23b1789e1f68485e78
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447044B2

Reaction notes

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