Pentanenitrile, 4,4-dimethyl-3-oxo- → 3-(Tert-butyl)-1-(3-pyridyl)pyrazole-5-amine

HRID 631669

Reaction equation

HRID 631669 reaction equation
[NH:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1)[NH2:2].[CH3:9][C:10]([CH3:17])([CH3:16])[C:11](=O)[CH2:12][C:13]#[N:14]>>[C:10]([C:11]1[CH:12]=[C:13]([NH2:14])[N:1]([C:3]2[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=2)[N:2]=1)([CH3:17])([CH3:16])[CH3:9]

Participants

3

Reactant 2

HCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-HCID 109095193-Hydrazinopyridine

Product 1

HCID 461967753-(Tert-butyl)-1-(3-pyridyl)pyrazole-5-amineYield 77.3%

Procedure

Following the procedure in Example 161A Step 3, 3-hydrazinylpyridine (501 mg, 4.0 mmol) and 4,4-dimethyl-3-oxopentanenitrile (437 mg, 4.0 mmol) were reacted to give 3-tert-butyl-1-(pyridin-3-yl)-1H-pyrazol-5-amine (667 mg, 3.09 mmol, 77%), LC-MS (ESI) m/z 217 (M+H)+.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-529e66e89a164ed6a369230e2e7b8c01
Source dataset
uspto-grants-2016_04
Patent number
US09320739B2

Linked notes

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