m-Chloroperbenzoic acid → 2-Chloro-4-methylpyridine 1-oxide

Temperature

0 °C

2-Chloro-4-methylpyridine (1 g, 7.84 mmol) was dissolved in DCM (10 ml), cooled to 0° C., mCPBA (70%, 2.32 g, 9.41 mmol) was added and the mixture was stirred at 0° C. for several hours and allowed to reach room temperature overnight. The mixture was diluted with DCM and washed with saturated Na2S2O3 solution and saturated sodium bicarbonate solution. After drying (sodium sulfate) and concentration under reduced pressure, 1.0 g of a yellow oil was obtained (6.27 mmol, 80%) MS(ESI) m/z=144.0 [M+1]+.

1. washwashed with saturated Na2S2O3 solution and saturated sodium bicarbonate solution
2. customAfter drying
3. concentration(sodium sulfate) and concentration under reduced pressure

ORD record

ord-8377b7d595bc4d13b1e0b8a8fc18f5b2

Source dataset

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09321724B2