2-Amino-2-methyl-1-propanol → 5-Cyclopropylamino-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

HRID 632215

Reaction equation

HRID 632215 reaction equation
[CH:1]1([NH:4][C:5]2[CH:6]=[CH:7][C:8]([C:16]([OH:18])=O)=[N:9][C:10]=2[O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[CH2:3][CH2:2]1.[NH2:19][C:20]([CH3:24])([CH3:23])[CH2:21][OH:22]>>[OH:22][CH2:21][C:20]([NH:19][C:16]([C:8]1[CH:7]=[CH:6][C:5]([NH:4][CH:1]2[CH2:2][CH2:3]2)=[C:10]([O:11][CH2:12][CH:13]2[CH2:14][CH2:15]2)[N:9]=1)=[O:18])([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 710871915-Cyclopropylamino-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 711056345-Cyclopropylamino-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropylamino-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 133 b) and 2-amino-2-methyl-1-propanol (CAN 124-68-5) as starting materials, MS (EI): m/e=401.1 [M+H]+.

Sources & evidence

ORD record
ord-4b2fdf2c891b467ca3badcc500cbfce5
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Linked notes

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