Cyclopropanecarbonyl chloride → 2-[(Cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl thiocyanate

HRID 633502

Reaction equation

HRID 633502 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([S:11][C:12]#[N:13])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH:14]1([C:17](Cl)=[O:18])[CH2:16][CH2:15]1>N1C=CC=CC=1>[CH:14]1([C:17]([NH:1][C:2]2[S:3][C:4]3[CH:10]=[C:9]([S:11][C:12]#[N:13])[CH:8]=[CH:7][C:5]=3[N:6]=2)=[O:18])[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 816002-Amino-6-thiocyanato-1,3-benzothiazole

Product 1

HCID 866478942-[(Cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl thiocyanateYield 99.7%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The 2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl thiocyanate was prepared in a manner similar to the method described in Example 18b, but using 2 g of commercial 2-amino-6-thiocyanatobenzothiazole and 1.21 g of cyclopropanecarboxylic acid chloride in 20 cm3 of pyridine after reaction for 5 h at 20° C. 2.65 g of 2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl thiocyanate are thus obtained in the form of a yellow powder, the characteristics of which are as follows:

Workup

  1. customThe 2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl thiocyanate was prepared in a manner similar to the method
  2. customafter reaction for 5 h at 20° C

Sources & evidence

ORD record
ord-512e6b498c194df7aaec06b9dfc6a581
Source dataset
uspto-grants-2016_04
Patent number
US09321777B2

Linked notes

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