Ammonium Hydroxide → 1-(2-Aminopyridin-5-yl)ethanone
Reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[OH-].[NH4+:12]>>[NH2:12][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1Participants
3
Conditions
- Temperature
- 130 °C
Procedure
2 g (11.57 mmol) of 1-(6-chloropyrid-3-yl)ethanone and 70 mL of ammonium hydroxide are placed in a Parr reactor. The solution is heated at 130° C. overnight. The mixture obtained is evaporated to dryness, and the residue is taken up in ethyl acetate and washed with water and with saturated NaCl solution. The organic phase is dried over sodium sulfate and evaporated to dryness to give 1.14 g of 1-(6-aminopyrid-3-yl)ethanone, the characteristics of which are as follows:
Workup
- customThe mixture obtained
- customis evaporated to dryness
- washwashed with water and with saturated NaCl solution
- dry with materialThe organic phase is dried over sodium sulfate
- customevaporated to dryness
Sources & evidence
- ORD record
- ord-bb41f7a833024d76b26c12616ecec026
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09321790B2
Reaction notes
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