Hydrochloric Acid → 5-((Azetidin-3-yloxy)methyl)thiazole hydrochloride
Reaction equation
[ClH:1].[S:2]1[C:6]([CH2:7][O:8][CH:9]2[CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)=[CH:5][N:4]=[CH:3]1>C(OCC)C>[ClH:1].[NH:11]1[CH2:12][CH:9]([O:8][CH2:7][C:6]2[S:2][CH:3]=[N:4][CH:5]=2)[CH2:10]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of HCl in diethylether (2N, 5.5 mL) was added to a solution of tert-butyl 3-(thiazol-5-ylmethoxy)-azetidine-1-carboxylate (150 mg, 0.55 mmol) in diethylether (2 mL) at room temperature. The reaction mixture was stirred 30 minutes then concentrated to dryness. After trituration in diethyl ether (10 mL), the title compound was obtained as a yellow solid (113 mg, quantitative).
Workup
- concentrationthen concentrated to dryness
Sources & evidence
- ORD record
- ord-18436d2da3524894b492a962acc2dd24
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09321769B2
Reaction notes
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