Bromine → 2-Amino-5-bromonicotinaldehyde hydrobromide
Reaction equation
[Br:1]Br.[NH2:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][CH:7]=[CH:6][N:5]=1>C(O)(=O)C>[BrH:1].[NH2:3][C:4]1[N:5]=[CH:6][C:7]([Br:1])=[CH:8][C:9]=1[CH:10]=[O:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of bromine (1.05 mL, 20.0 mmol) in acetic acid (20 mL) was added to a solution of 2-amino-3-pyridinecarboxaldehyde (2.5 g, 20 mmol) in acetic acid (50 mL) at room temperature. The reaction mixture was then stirred overnight. The resulting precipitate was filtered and washed with diethyl ether to give the title compound as a white solid (4.66 g, 80%).
Workup
- filtrationThe resulting precipitate was filtered
- washwashed with diethyl ether
Sources & evidence
- ORD record
- ord-7d7ab6aa56a64900bf92e710f3f0f273
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09321769B2
Reaction notes
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