Phenylboronic Acid → tert-butyl 1-(1-oxo-4-phenyl-1H-isochromen-3-yl)ethylcarbamate
Reaction equation
OC(C1[O:5][C:6](=[O:20])[C:7]2[C:12](C=1C1C=CC=CC=1)=[CH:11][CH:10]=[CH:9][CH:8]=2)C.Br[C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)C(=O)O[C:23]=1[CH:33]([NH:35][C:36](=[O:42])[O:37][C:38]([CH3:41])([CH3:40])[CH3:39])[CH3:34].C1(B(O)O)C=CC=CC=1>>[O:20]=[C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:22]([C:31]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[C:23]([CH:33]([NH:35][C:36](=[O:42])[O:37][C:38]([CH3:41])([CH3:40])[CH3:39])[CH3:34])[O:5]1Participants
4
Procedure
The title compound was made in a way similar to that of intermediate B1 from tert-butyl 1-(4-bromo-1-oxo-1H-isochromen-3-yl)ethylcarbamate (Intermediate A3, 500 mg, 1.358 mmol), phenylboronic acid (215 mg, 1.765 mmol), to give the title compound (112 mg, 22.6%) as a yellowish oil.