Hydroxyamine hydrochloride → 2,2-Dimethyl-4-chromanone oxime

HRID 635903

Reaction equation

HRID 635903 reaction equation
[CH3:1][C:2]1([CH3:13])[CH2:11][C:10](=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[O:3]1.Cl.[NH2:15][OH:16]>CO.N1C=CC=CC=1>[CH3:1][C:2]1([CH3:13])[CH2:11][C:10](=[N:15][OH:16])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[O:3]1

Participants

5

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 74542902,2-Dimethyl-chroman-4-one

Product 1

HCID 1317223932,2-Dimethyl-4-chromanone oxime

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 1049PyridineSolvent

Conditions

Temperature
82.5 °C

Procedure

A reaction mixture prepared from 10 mmol of 2,2-dimethyl-4-chromanone, 12 mmol of hydroxylamine hydrochloride in 5 ml of methanol and 5 ml of pyridine is heated with stirring over the course of 2 hours to 80-85° C., the solvent is distilled off on a rotary evaporator and the oily residue is crystallized under water.

Workup

  1. temperatureis heated
  2. distillationthe solvent is distilled off on a rotary evaporator
  3. customthe oily residue is crystallized under water

Sources & evidence

ORD record
ord-8b926752e5bb4b5da7a24ab2bf4e3a79
Source dataset
uspto-grants-2001_02
Patent number
US06191164B1

Linked notes

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