5-Azaindole → 3-(1-Methyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-azaindole

HRID 635924Notes

Reaction equation

HRID 635924 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][N:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[CH3:10][N:11]1[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]1.N1CCCC1>C(O)C>[CH3:10][N:11]1[CH2:12][CH:13]=[C:14]([C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[N:6][CH:5]=3)[NH:1][CH:2]=2)[CH2:15][CH2:16]1

Participants

5

Reactant 3

HCID 92205-AzaindoleHCID 31268PyrrolidineHCID 740491-Methyl-4-piperidone

Product 1

HCID 97943653-(1-Methyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-azaindole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

from 5-azaindole (2.0 g, 16.9 mmol); N-methyl-4-piperidone (1.92 g , 16.9 mmol) and pyrrolidine (12.04 g, 169 mmol) in ethanol (20 mL).

Sources & evidence

ORD record
ord-18d1d24ddb4e41f3bb9d4ae02389cc7d
Source dataset
uspto-grants-2001_02
Patent number
US06191141B1

Reaction notes

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