Hydrogen Sulfide → HCID 178478026, compound

First, 35.6 mmol of 2-chlorobenzonitrile was dissolved in 50 ml of methanol, and 35.6 mmol of triethylamine and 105 mmol of hydrogen sulfide were added thereto at room temperature, followed by adding 180 mmol of anhydrous hydrazine and keeping at the reflux temperature for 48 hours. The reaction mixture was evaporated under reduced pressure. The residue was dissolved in 50 ml of 5% hydrochloric acid, and 75 mmol of sodium nitrite was added thereto at 0° C. to cause reaction. After completion of the reaction, the reaction mixture was extracted with ethyl acetate to give 5-(2-chlorophenyl)tetrazole. Yield, 54%

1. customat room temperature
2. customThe reaction mixture was evaporated under reduced pressure
3. dissolutionThe residue was dissolved in 50 ml of 5% hydrochloric acid
4. customat 0° C.
5. customreaction
6. customAfter completion of the reaction
7. extractionthe reaction mixture was extracted with ethyl acetate

ORD record

ord-43d44fb86f0d4bcdbdd9a8df4407281f

Source dataset

uspto-grants-2001_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06191289B1