Chlorosuccinimide → HCID 15434360, compound

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:8]3[C:12](=[C:13]([C:15]([NH2:17])=[O:16])[CH:14]=2)[CH2:11][CH2:10][CH2:9]3)[CH:2]=1.[Cl:18]N1C(=O)CCC1=O>>[Cl:18][C:14]1[C:13]([C:15]([NH2:17])=[O:16])=[C:12]2[N:8]([CH2:9][CH2:10][CH2:11]2)[C:7]=1[C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 31398Chlorosuccinimide

HCID 133754925-(Pyridin-3-yl)-2,3-dihydro-1H-pyrrolizine-7-carboxamide

Product 1

HCID 15434360HCID 15434360, compound

Procedure

6-Chloro-5-(3-pyridyl)-2,3-dihydropyrolizine-7-carboxamide is prepared as described in Example 45, from 0.45 g of 5-(3-pyridyl)-2,3-dihydropyrrolizine-7-carboxamide and 0.29 g of N-chlorosuccinimide. 0.27 g of expected product are thus obtained in the form of cream powder which melts at 215° C.

Sources & evidence

ORD record: ord-3da1cfc89f6a4fd4a8f602961625ff2d
Source dataset: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06194426B1

Reaction notes

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