Hydrazine → 1-Pyrrolidinamine
Reaction equation
NN.C(O)(O)CCC.[NH2:9][N:10]1[CH2:14][CH2:13][CH2:12][CH2:11]1>O1CCCC1>[NH2:9][N:10]1[CH2:14][CH2:13][CH2:12][CH2:11]1.[NH:10]1[CH:14]=[CH:13][CH2:12][CH2:11][NH:9]1Participants
6
Reactant 3
Product 2
Reagents, catalysts & solvents 1
Procedure
Thus, 1-aminopyrrolidine is synthesized from hydrazine hydrohalogenic acid salt and butane diol or tetrahydrofuran, and by oxidizing 1-aminopyrrolidine with an oxidizing agent to form tetrahydropyridazine, and next, the tetrahydropyridazine is hydrogenated by using a noble metal catalyst to produce with industrial and economical advantages hexahydropyridazine which is very useful as an intermediate for agricultural chemicals or medicines.
Sources & evidence
- ORD record
- ord-4e1ac66220174ddb9e6725d8eea37d67
- Source dataset
- uspto-grants-2001_02
- Patent number
- US06194577B1
Reaction notes
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