4-(1-Imidazolyl)benzoic Acid → Carbon Dioxide

HRID 637303

Reaction equation

HRID 637303 reaction equation
[CH2:1]([C:3]1[NH:7][C:6](=[O:8])[NH:5][C:4]=1[C:9]([OH:11])=[O:10])[CH3:2].[N:12]1([C:17]2[CH:25]=[CH:24][C:20]([C:21]([OH:23])=O)=[CH:19][CH:18]=2)[CH:16]=[CH:15][N:14]=[CH:13]1>[OH-].[Na+]>[C:9](=[O:11])=[O:10].[CH2:1]([C:3]1[NH:7][C:6](=[O:8])[NH:5][C:4]=1[C:21](=[O:23])[C:20]1[CH:19]=[CH:18][C:17]([N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:25][CH:24]=1)[CH3:2]

Participants

5

Reactant 2

HCID 7365294-(1-Imidazolyl)benzoic AcidHCID 138159895-Ethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid

Product 2

HCID 280Carbon DioxideHCID 127769CK 2289

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

In a manner similar to that described in Example IA react 5-ethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid and 4-(1H-imidazol-1-yl)benzoic acid, dissolve the crude free base in aqueous sodium hydroxide and reprecipitate with carbon dioxide to produce the title compound.

Sources & evidence

ORD record
ord-bb69656e41b64be39d5500152f332783
Source dataset
uspto-grants-1985_12
Patent number
US04556665

Linked notes

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