Hydrochloric Acid → 2,2,3,3-Tetrafluoro-3-methoxypropanoic acid
Reaction equation
[OH-].[Na+].[CH3:3][O:4][C:5]([F:14])([F:13])[C:6]([F:12])([F:11])[C:7]([O:9]C)=[O:8].Cl>O>[CH3:3][O:4][C:5]([F:13])([F:14])[C:6]([F:11])([F:12])[C:7]([OH:9])=[O:8]Participants
5
Procedure
A mixture of 32 g sodium hydroxide, 400 g water and 152 g methyl 3-methoxytetrafluoropropionate was stirred at room temperature until a single liquid layer was obtained. The product was acidified with 37% aqueous HCl and the lower layer separated. The aqueous layer was extracted four times with 50 ml ethyl ether and the combined ether extracts and lower layer distilled to give 103.3 g (73.4%) 3-methoxytetrafluoropropionic acid, b.p. 85°-86° at 20 mm.
Workup
- customwas obtained
- customthe lower layer separated
- extractionThe aqueous layer was extracted four times with 50 ml ethyl ether
- distillationthe combined ether extracts and lower layer distilled
Sources & evidence
- ORD record
- ord-fb11c3c9928b47c6b52d4059333a69c8
- Source dataset
- uspto-grants-1985_12
- Patent number
- US04556747
Reaction notes
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