Propanal → Ethyl 3-chloro-2-oxopentanoate

Temperature

0 °C

Sodium ethoxide (0.68 g, 9.94 mmol) was added portionwise to a mixture of ethyldichloroacetate (1.22 ml, 9.94 mmol) and diethyl ether (10 ml) under ice-water cooling and the resulting mixture was stirred at 0° C. for 30 minutes. Propionaldehyde (0.79 ml, 10.93 mmol) was then added and the reaction mixture allowed to warm to room temperature slowly and stirring continued for 72 hours. The reaction mixture was then poured onto water (10 ml) and extracted with diethyl ether (2×15 ml). The organic layers were combined, dried over magnesium sulfate, and concentrated in vacuo to yield crude 3-chloro-2-oxo-pentanoic acid ethyl ester (1.8 g) which was used in the next step without further purification.

1. temperatureto warm to room temperature slowly
2. stirringstirring
3. waitcontinued for 72 hours
4. additionThe reaction mixture was then poured onto water (10 ml)
5. extractionextracted with diethyl ether (2×15 ml)
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated in vacuo

ORD record

ord-5308c45182cf4ab583db80ba46a4ea2d

Source dataset

uspto-grants-2010_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07700634B2