Tert-Butylamine → N-(tert-Butyl)-2-(1-piperazinyl)acetamide dihydrochloride

HRID 645759

Reaction equation

C(OC(N1CCNCC1)=O)(C)(C)C.[Cl:14]CC(Cl)=O.[C:19]([NH2:23])([CH3:22])([CH3:21])[CH3:20].[ClH:24].Cl.COCC(N[C:32](=[O:40])[CH2:33][N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)C>>[ClH:14].[ClH:24].[C:19]([NH:23][C:32](=[O:40])[CH2:33][N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)([CH3:22])([CH3:21])[CH3:20]

Participants

Reactant 4

HCID 6385Tert-Butylamine

HCID 6577Chloroacetyl chloride

HCID 143452tert-Butyl piperazine-1-carboxylate

HCID 67245894N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide dihydrochloride

Product 1

HCID 16246646N-(tert-Butyl)-2-(1-piperazinyl)acetamide dihydrochloride

Procedure

N-tert-butyl-2-piperazin-1-yl-acetamide dihydrochloride was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetylchloride and N-tert-butylamine in an analogous manner as described for the preparation of N-(2-methoxy-1-methyl-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride (example 40).

Sources & evidence

ORD record: ord-a6ec88f12531480cba0c162d28297433
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07705007B2

Linked notes

Loading…