Hydrochloric Acid → Methyl 6-oxohexanoate

HRID 64589

Reaction equation

HRID 64589 reaction equation
[CH3:1][O:2][C:3](=[O:13])[CH2:4][CH2:5][CH2:6][CH2:7][CH:8](OC)[O:9]C.Cl>CO>[C:3]([CH2:4][CH2:5][CH2:6][CH2:7][CH:8]=[O:9])([O:2][CH3:1])=[O:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11041551Methyl 6,6-dimethoxyhexanoate

Product 1

HCID 81164Methyl 6-oxohexanoate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

After the reaction, MeOH was recovered, following by the same treatment as above to give 9.47 g. of crude 6,6-dimethoxycaproic acid methyl ester. Then, a 10 wt.% aqueous hydrochloric acid solution was added to this crude product, followed by stirring for 6 hours at room temperature. The reaction mixture was treated by usual method to give crude products. Pure 3.20 g. of 5-carbomethoxy-1-pentanal was obtained by column chromatography.

Workup

  1. customwas recovered
  2. customto give 9.47 g
  3. additionThe reaction mixture was treated by usual method
  4. customto give crude products

Sources & evidence

ORD record
ord-18e99ebb93034446a33f27fb49e9b384
Source dataset
uspto-grants-1986_09
Patent number
US04609492

Linked notes

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