1-Methylpiperazine → 1-Methyl-4-[3-(4-methyl-piperidin-1-yl)-4-nitro-phenyl]-piperazine

HRID 646858

Reaction equation

HRID 646858 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:15]([O-:17])=[O:16])=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([CH3:14])[CH2:10][CH2:9]2)[CH:7]=1.[CH3:18][N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:18][N:19]1[CH2:24][CH2:23][N:22]([C:2]2[CH:3]=[CH:4][C:5]([N+:15]([O-:17])=[O:16])=[C:6]([N:8]3[CH2:13][CH2:12][CH:11]([CH3:14])[CH2:10][CH2:9]3)[CH:7]=2)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 586385011-(5-Chloro-2-nitro-phenyl)-4-methyl-piperidine

Product 1

HCID 586385301-Methyl-4-[3-(4-methyl-piperidin-1-yl)-4-nitro-phenyl]-piperazineYield 100.8%

Procedure

The procedure of Example 4, step (b) was followed using 150 mg (0.589 mmol) of 1-(5-chloro-2-nitro-phenyl)-4-methyl-piperidine (as prepared in the Example 12, step (a)) and 327 μL (2.95 mmol) of 1-methylpiperazine at 142° C. for 21 h to afford 189 mg (100%) of the title compound as a yellow semisolid: Mass spectrum (ESI, m/z): Calcd. for C16H24N4O2, 319.2 (M+H), found 319.1.

Sources & evidence

ORD record
ord-b2725cddc45a4bf28b59119e4f0ca6c8
Source dataset
uspto-grants-2010_04
Patent number
US07705042B2

Linked notes

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