Thionyl Chloride → 6,6-Difluorohex-5-enoic acid chloride
Reaction equation
S(Cl)([Cl:3])=O.[F:5][C:6]([F:14])=[CH:7][CH2:8][CH2:9][CH2:10][C:11](O)=[O:12]>CN(C)C=O>[F:5][C:6]([F:14])=[CH:7][CH2:8][CH2:9][CH2:10][C:11]([Cl:3])=[O:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
10.23 ml (140.68 mmol) Thionyl chloride was added dropwise to 8.0 g (52.29 mmol) of the product of Example 9 at room temperature. A drop of dimethylformamide was added and the mixture heated under reflux for 6 hours. It was then distilled under reduced pressure.
Workup
- temperaturethe mixture heated
- temperatureunder reflux for 6 hours
- distillationIt was then distilled under reduced pressure
Sources & evidence
- ORD record
- ord-d30cf53005b044ea9db9fca6b67dce41
- Source dataset
- uspto-grants-1993_09
- Patent number
- US05248810
Reaction notes
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