4-Chlorophenol → 4-Chloro-1-(4-chlorophenoxy)-2-butanol

HRID 64695

Reaction equation

HRID 64695 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[CH2:10][CH:11]([OH:15])[CH2:12][CH2:13][Cl:14].[OH-].[Na+]>O>[Cl:14][CH2:13][CH2:12][CH:11]([OH:15])[CH2:10][O:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1

Participants

5

Reactant 3

HCID 46844-ChlorophenolHCID 14798Sodium HydroxideHCID 170211,4-Dichloro-2-butanol

Product 1

HCID 131203494-Chloro-1-(4-chlorophenoxy)-2-butanol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-Chloro-1-(4-chlorophenoxy)-2-butanol was prepared using the procedure of Preparation 7 from 45 g. (0.5 mole) of p-chlorophenol, 72 g. (0.5 mole) of 1,4-dichloro-2-butanol, 40 g. (1.0 mole) of sodium hydroxide and 400 ml. of water to give 85 g. (36.1%) of product which melted at 62°-64° C. after recrystallization from isopropanol.

Workup

  1. customthe procedure of Preparation 7 from 45 g
  2. custom(36.1%) of product which melted at 62°-64° C. after recrystallization from isopropanol

Sources & evidence

ORD record
ord-b8932352aad64fcea11992d6264bd36e
Source dataset
uspto-grants-1986_09
Patent number
US04609735

Linked notes

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