Formic Acid → 2-(N-methylformamido)-4-methyl-5-acetylthiazole
Reaction equation
[CH3:1][NH:2][C:3]1[S:4][C:5]([C:9](=[O:11])[CH3:10])=[C:6]([CH3:8])[N:7]=1.[C:12](OC(=O)C)(=[O:14])C.C(O)=O>O1CCCC1>[CH3:1][N:2]([C:3]1[S:4][C:5]([C:9](=[O:11])[CH3:10])=[C:6]([CH3:8])[N:7]=1)[CH:12]=[O:14]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2-methylamino-4-methyl-5-acetylthiazole (35 g) in tetrahydrofuran (700 ml) were added a mixture of acetic anhydride (94.5 ml) and formic acid (37.7 ml) at ambient temperature and the mixture was stirred for two hours. The reaction mixture was evaporated in vacuo. The residue was added to water and the resultant precipitate was collected by filtration and dried over phosphorus pentoxide to give 2-(N-methylformamido)-4-methyl-5-acetylthiazole (39.59 g).
Workup
- customThe reaction mixture was evaporated in vacuo
- additionThe residue was added to water
- filtrationthe resultant precipitate was collected by filtration
- dry with materialdried over phosphorus pentoxide
Sources & evidence
- ORD record
- ord-09b89f4c666442e58164e968c0be0229
- Source dataset
- uspto-grants-1988_04
- Patent number
- US04735957
Reaction notes
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