Ethyl formate → 2-(N-Formyl-2-amino-ethyl)-furan

Reaction equation

[NH2:1][CH2:2][CH2:3][C:4]1[O:5][CH:6]=[CH:7][CH:8]=1.[CH:9](OCC)=[O:10]>>[CH:9]([NH:1][CH2:2][CH2:3][C:4]1[O:5][CH:6]=[CH:7][CH:8]=1)=[O:10]

Participants

Reactant 2

HCID 8025Ethyl formate

HCID 11328632-(Furan-2-yl)ethan-1-amine

Product 1

HCID 137469342-(N-Formyl-2-amino-ethyl)-furan

Procedure

Here, 2-(2-amino-ethyl)furan (10.0 g, 0.090 mol) is refluxed with ethyl formate (80 ml, 1.0 mol) for 12 hours. The reaction product is concentrated by evaporation and distilled in vacuo.

Workup

concentrationThe reaction product is concentrated by evaporation
distillationdistilled in vacuo

Sources & evidence

ORD record: ord-c39f5eca83bd43319f039e3f8864241f
Source dataset: uspto-grants-1988_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04737495

Reaction notes

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