1H-Benzimidazole, 5,6-dichloro-1-ethyl-2-methyl- → HCID 178462747, compound

HRID 649493

Reaction equation

[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][C:5]2[N:6]([CH2:10][CH3:11])[C:7]([CH3:9])=[N:8][C:4]=2[CH:3]=1.Cl[CH2:16][CH2:17][NH:18][S:19]([CH3:22])(=[O:21])=[O:20]>C1(OC)C=CC=CC=1>[Cl-:1].[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][C:5]2[N+:6]([CH2:10][CH3:11])=[C:7]([CH3:9])[N:8]([CH2:16][CH2:17][NH:18][S:19]([CH3:22])(=[O:21])=[O:20])[C:4]=2[CH:3]=1

Participants

Conditions

Temperature: 150 °C

Procedure

22.9 g (0.1 mol) of 5,6-dichloro-1-ethyl-2-methylbenzoimidazole and 23.6 g (0.15 mol) of N-(2-chloroethyl)methanesulfonamide were put into a 200-ml three-necked flask equipped with a stirrer and heated with stirring for 2 hours on an oil bath which had been heated to a temperature of 150° C. Then, 20 ml of anisole was added to the mixture. The mixture was then allowed to cool to room temperature with stirring. The resulting crystals were filtered off, washed with acetone and isopropanol, and dried.

Workup

customequipped with a stirrer
temperatureheated
temperatureto cool to room temperature
stirringwith stirring
filtrationThe resulting crystals were filtered off
washwashed with acetone and isopropanol
customdried

Sources & evidence

ORD record: ord-a56c3e55fb414f519a9b494eeb94be17
Source dataset: uspto-grants-1988_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04740455

Linked notes

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