NC1C2C3C=CC=CC=3SC=2NC2C=C(F)C=CC=2N=1.[ClH:21].FC1C=CC2N=[C:28]([N:39]3[CH2:44][CH2:43][N:42](CCC)[CH2:41][CH2:40]3)[C:29]3C4C=CC=CC=4S[C:30]=3NC=2C=1>CS(C)=O>[ClH:21].[CH2:28]([N:39]1[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]1)[CH2:29][CH3:30]
In the same manner as in Example 42 and using 12-amino-8-fluoro-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine.1 hydrochloride (1.5 g), N-n-propylpiperazine (17 g), dimethyl sulfoxide (10 ml) and hydrochloric acid, crude crystals (850 mg) of 8-fluoro-12-(4-propylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine were obtained. The crude crystals were dissolved in ethyl acetate (12 ml) and a solution of 5.5 mol/l hydrochloric acid in ether was added to give 8-fluoro-12-(4-propylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine.2 hydrochloride.1.5 hydrate (757 mg).
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