Lilial → HCID 11012960, compound

HRID 650252

Reaction equation

HRID 650252 reaction equation
C([BH3-])#N.[Na+].[Cl:5][C:6]1[N:11]=[CH:10][C:9]([CH2:12][NH2:13])=[CH:8][CH:7]=1.[C:14]([C:18]1[CH:23]=[CH:22][C:21]([CH2:24][CH:25]([CH3:28])[CH:26]=O)=[CH:20][CH:19]=1)([CH3:17])([CH3:16])[CH3:15]>CO>[C:14]([C:18]1[CH:19]=[CH:20][C:21]([CH2:24][CH:25]([CH3:28])[CH2:26][NH:13][CH2:12][C:9]2[CH:10]=[N:11][C:6]([Cl:5])=[CH:7][CH:8]=2)=[CH:22][CH:23]=1)([CH3:17])([CH3:16])[CH3:15]

Participants

5

Reactant 3

HCID 228987LilialHCID 5003444Sodium cyanoborohydrideHCID 70209275-(Aminomethyl)-2-chloropyridine

Product 1

HCID 11012960HCID 11012960, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Route A: After suspending 620 mg (9.84 mmol) of sodium cyanoborohydride in 2 ml of absolute methanol, 700 mg (4.91 mmol) of 6-chloro-3-pyridylmethylamine was added thereto. Subsequently, to this was added a solution of 1.0 g (4.90 mmol) 3-(4-t-butylphenyl)-2-methylpropionaldehyde/2 ml absolute methanol by portions and then, stirring was conducted at room temperature for 4 h.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-6b8c0a22c7ca4e8ea28cefd9cd3dcabd
Source dataset
uspto-grants-2001_08
Patent number
US06271385B1

Linked notes

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