Phosgene → HCID 21709913, compound

Reaction equation

[C:1]([Cl:4])(Cl)=[O:2].[CH3:5][NH:6][CH:7]1[CH2:12][CH2:11][S:10][CH2:9][CH2:8]1.C(N(CC)CC)C>>[CH3:5][N:6]([CH:7]1[CH2:12][CH2:11][S:10][CH2:9][CH2:8]1)[C:1]([Cl:4])=[O:2]

Participants

Reactant 3

HCID 6371Phosgene

HCID 8471Triethylamine

HCID 21709907HCID 21709907, compound

Product 1

HCID 21709913HCID 21709913, compound

Procedure

Similarly to the method described in intermediate 1.2, 22.8 g (0.23 mol) of phosgene, 10 g (76 mmol) of methyl(tetrahydro-2H-thiopyran-4-yl)amine and 7.8 g (76 mmol) of triethylamine were reacted. Yield 13.4 g. MS (m/z): 193 [M]+, 158 [M−Cl]+.

Workup

customwere reacted

Sources & evidence

ORD record: ord-0fa8132e9eaf49ad8b8d104a8bd6f460
Source dataset: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06277790B1

Reaction notes

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