Methyl 2-[2-(dimethylamino)ethoxy]benzoate → 2-(2-Dimethylamino-ethoxy)-benzoic acid
Reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][O:6][C:7]1[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=1[C:9]([O:11]C)=[O:10])[CH3:3]>Cl>[CH3:3][N:2]([CH2:4][CH2:5][O:6][C:7]1[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=1[C:9]([OH:11])=[O:10])[CH3:1]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
4.4 g of methyl 2-[2-(N,N-dimethylamino)ethyl]oxy-benzoate are heated in the microwave for 15 minutes at 300 W with 30 ml of 5N hydrochloric acid. The mixture is extracted with ethyl acetate, the aqueous phase is concentrated by evaporation and recrystallised from acetonitrile/ether. Yield: 4.2 g (86% of theory).
Workup
- extractionThe mixture is extracted with ethyl acetate
- concentrationthe aqueous phase is concentrated by evaporation
- customrecrystallised from acetonitrile/ether
Sources & evidence
- ORD record
- ord-255bebdb22d24c1199dd173a72b94a50
- Source dataset
- uspto-grants-2001_08
- Patent number
- US06277872B1
Reaction notes
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