Allylamine → HCID 13747166, compound
Reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[CH:9]=[N:10][NH:11][C:3]=12.[CH2:12]([NH2:15])[CH:13]=[CH2:14]>O>[CH2:12]([NH:15][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[CH:9]=[N:10][NH:11][C:3]=12)[CH:13]=[CH2:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) (1.0 g, 0.006 mole) and allylamine (60 g) in water (100 ml) was heated under reflux for 12 days. On cooling the reaction mixture was evaporated to dryness, basified to pH8 with 10% sodium carbonate solution and the resulting solid filtered off. Recrystallisation from chloroform/pentane gave the product as white solid (1.0 g). m.p. 172°-174° C.
Workup
- temperaturewas heated
- temperatureunder reflux for 12 days
- temperatureOn cooling the reaction mixture
- customwas evaporated to dryness
- filtrationthe resulting solid filtered off
- customRecrystallisation from chloroform/pentane
Sources & evidence
- ORD record
- ord-8ceafe762bf746c1b5531cc156e2df43
- Source dataset
- uspto-grants-1987_06
- Patent number
- US04670432
Reaction notes
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