HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Ethyl 4-[14-(trimethylsilyl)tetradecylamino]benzoylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | tert-Butyl ethyl 4-[14-(trimethylsilyl)tetradecylamino]benzoylmalonate | HCID 20198261 | — |
| Product | Ethyl 4-[14-(trimethylsilyl)tetradecylamino]benzoylacetate | HCID 20198260 | — |
Reaction Steps
A solution of 3.0 g. of tert-butyl ethyl 4-[14-(trimethylsilyl)tetradecylamino]benzoylmalonate and 10 ml. of trifluoroacetic acid is warmed with stirring for 3 hours. The solution is poured onto ice and neutralized with potassium hydroxide. The resulting precipitate is collected by filtration, washed with water and dried. Recrystallization affords the product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04670421 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-72e4124e5c5e4f489fda6adeebfa3568 |
| Source note | uspto-grants-1987_06 |