2-Mesitylenesulfonic acid dihydrate → 2,4,6-Trimethylbenzenesulfonic acid

HRID 652828Notes

Reaction equation

HRID 652828 reaction equation
O.O.[C:3]1([CH3:15])[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH3:10])[C:4]=1[S:11]([OH:14])(=[O:13])=[O:12]>C(OCC)(=O)C>[C:3]1([CH3:15])[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH3:10])[C:4]=1[S:11]([OH:14])(=[O:13])=[O:12]

Participants

3

Reactant 1

HCID 156203442-Mesitylenesulfonic acid dihydrate

Product 1

HCID 769922,4,6-Trimethylbenzenesulfonic acidYield 348.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of 2.5 g of mesitylenesulfonic acid dihydrate in 20 ml of ethyl acetate was added to a solution of 5.93 g of pivaloyloxymethyl 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-[2-(5-methyl-1,2,3,4-tetrazolyl)methyl]-Δ3 -cephem-4-carboxylate in 50 ml of ethyl acetate. The deposited crystals were collected by filtration, washed with ethyl acetate and dried to obtain 7.39 g (yield 93.2%) of mesitylenesulfonic acid salt of pivaloyloxymethyl 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-[2-(5-methyl-1,2,3,4-tetrazolyl)methyl]-Δ3 -cephem-4-carboxylate having a melting point of 218°-220° C. (decomp.).

Workup

  1. filtrationThe deposited crystals were collected by filtration
  2. washwashed with ethyl acetate
  3. customdried

Sources & evidence

ORD record
ord-a12a0eea5bd44b08a45c6c0114ea61ca
Source dataset
uspto-grants-1987_06
Patent number
US04673738

Reaction notes

Loading…