2,3-Dichloroanisole → 2,3-Dichloro-4-methoxy-4'-fluorobenzophenone

HRID 652879

Reaction equation

HRID 652879 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[Cl:11][C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[O:19][CH3:20].[Al+3].[Cl-].[Cl-].[Cl-]>ClCCCl>[Cl:18][C:17]1[C:12]([Cl:11])=[C:13]([O:19][CH3:20])[CH:14]=[CH:15][C:16]=1[C:6]([C:5]1[CH:9]=[CH:10][C:2]([F:1])=[CH:3][CH:4]=1)=[O:7]

Participants

5

Reactant 3

HCID 161262,3-DichloroanisoleHCID 678794-Fluorobenzoyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 201506312,3-Dichloro-4-methoxy-4'-fluorobenzophenone

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The Friedel-Crafts procedure of Example 24a is repeated with 31.55 g of p-fluorobenzoyl chloride, 32 g of 2,3-dichloroanisole and 35.22 g of AlCl3 combined in 1,2-dichloroethane and reacted. The resultant crude product is triturated with warm hexane, cooled and filtered to yield 2,3-dichloro-4-methoxy-4'-fluorobenzophenone.

Workup

  1. customreacted
  2. customThe resultant crude product is triturated with warm hexane
  3. temperaturecooled
  4. filtrationfiltered

Sources & evidence

ORD record
ord-16d2b1f25727477b870fde75392c2ede
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Linked notes

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