Hexane → 2-(3-Hydroxyphenyl)-2-oxoacetaldehyde

HRID 653044Notes

Reaction equation

HRID 653044 reaction equation
CCCCCC.[CH3:7][C:8]([C:10]1[CH:11]=[CH:12][CH:13]=[C:14]([OH:16])[CH:15]=1)=[O:9].C(OCC)(=[O:19])C>>[OH:16][C:14]1[CH:15]=[C:10]([C:8]([CH:7]=[O:19])=[O:9])[CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 8058HexaneHCID 84873-HydroxyacetophenoneHCID 8857Ethyl Acetate

Product 1

HCID 129108752-(3-Hydroxyphenyl)-2-oxoacetaldehyde

Procedure

Using 1:1 hexane:ethyl acetate as eluant, the method of Preparation 68 was employed to convert 3-hydroxyacetophenone (15.0 g., 0.11 mol) to present title product, 7.4 g.; 1H-nmr (DMSO-d6) 7.09 (m, 2H), 7.43 (m, 3H), 9.75 (br m, 1H).

Sources & evidence

ORD record
ord-02355845f5ff415e811e6659c2b78d5c
Source dataset
uspto-grants-1987_06
Patent number
US04675186

Reaction notes

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