Phenyl Isothiocyanate → ST50557383
Reaction equation
[C:1]1([N:7]=[C:8]=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:10]([NH:13][NH2:14])(=[O:12])[CH3:11]>C(O)C>[C:10]([NH:13][NH:14][C:8]([NH:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[S:9])(=[O:12])[CH3:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
By reacting 27 g of phenyl isothiocyanate and 15 g of acetylhydrazine in ethanol at room temperature, 1-acetyl-4-phenylthiosemicarbazide was formed, which was collected by filtration and refluxed in ethanol in the presence of sodium ethylate to provide 3-mercapto-5-methyl-4-phenyl-1,2,4-triazole.
Workup
- customat room temperature
Sources & evidence
- ORD record
- ord-30c969d8d7e6426aa013cef8fef11497
- Source dataset
- uspto-grants-1987_06
- Patent number
- US04675276
Reaction notes
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