HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-3-(trifluoromethyl)aniline → 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-3-(trifluoromethyl)aniline | HCID 75377 | — |
| Reactant | 4-(Chlorosulfonyl)benzoic acid | HCID 82385 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl)benzoic acid | HCID 3699990 | 908.4% |
Reaction Steps
Analogously to Example 10, 2.21 g (10 mmol) of 4-chlorosulfonyl-benzoic acid is reacted with 1.79 g (10 mmol) of 4-fluoro-3-(trifluoromethyl)-aniline in pyridine and the crude product is crystallized from ethanol. 3.3 g=90.84 mmol of crystalline product is obtained. Melting point 238°-241° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05130119 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-e0350539f1414eb2a75b9ac2d5afcda4 |
| Source note | uspto-grants-1992_07 |