5'-Atp → L-Tryptophan

HRID 655094

Reaction equation

HRID 655094 reaction equation
[CH2:1](OP(O)(O)=O)[C@H:2]1O[C@H:5](OP(OP(O)(O)=O)(O)=O)[C@H:4](O)[C@@H:3]1O.P(OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1O)(OP(OP(O)(O)=O)(O)=O)(=O)O.[NH2:54][C@H:55]([C:62]([OH:64])=[O:63])[CH2:56][C:57]1N=[CH:60][NH:59][CH:58]=1>>[NH2:54][C@H:55]([C:62]([OH:64])=[O:63])[CH2:56][C:57]1[C:5]2[C:60](=[CH:1][CH:2]=[CH:3][CH:4]=2)[NH:59][CH:58]=1

Participants

4

Reactant 3

HCID 59575'-Atp2×HCID 7339Phosphoribosyl Pyrophosphate2×HCID 178419078HCID 178419078, compound2×

Product 1

HCID 6305L-Tryptophan

Procedure

5-Phosphoribosyl-α-1-pyrophosphate (hereinafter, “PRPP”) and adenosine-5′-triphosphate (hereinafter, “ATP”) are the initial substrates in histidine biosynthesis. PRPP can sometimes induce the histidine biosynthesis to follow divergent pathways, resulting in the biosynthesis of pyrimidine nucleotides, purine nucleotides, pyridine nucleotides, and tryptophan (Escherichia coli and Salmonella, Second Edition, Editor in Chief: F. C. Neidhardt, ASM Press, Washington D.C., 1996).

Sources & evidence

ORD record
ord-8a93aaca8cfb4bda82219c51c57b8cd5
Source dataset
uspto-grants-2011_12
Patent number
US08071339B2

Linked notes

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