Reaction equation
N[C:2]1[CH:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=1.N([O-])=O.[Na+].[S:14]([Cl:17])(Cl)=[O:15].[OH2:18]>Cl.O>[C:8]([C:5]1[N:6]=[CH:7][C:2]([S:14]([Cl:17])(=[O:15])=[O:18])=[CH:3][CH:4]=1)#[N:9]Participants
Conditions
- Temperature
- -5 °C
Procedure
In parallel, 5-amino-2-cyano pyridine (10 g, 0.084 mol) is dissolved in concentrated HCl (98 ml) and the mixture is cooled to −5° C. To this mixture is added dropwise over a period of 1 h a solution of NaNO2 (8.2 g, 0.118 mol) in water (50 ml), maintaining the reaction temperature between −5° C. and 0° C. This slurry is then added dropwise over a period of 1 h to the above reaction mixture (thionylchloride/water mixture), maintaining the reaction temperature between −5° C. and 0° C. (Note: The diazotized mixture should be also kept at −5° C. through out the addition). As the addition proceeds, a white solid precipitates. When the addition is over, the reaction mixture is stirred for an additional hour. The precipitate is collected by filtration, washed with cold water and dried under vacuum to afford the title compound as light yellow solid (12.5 g, Yield 73.5%). 1H NMR (DMSO-d6:400 MHz) δ 14.49 (1H, s), 8.87 (1H, s), 8.11-8.14 (1H, d), 8.0-8.03 (1H, d); HPLC (max plot) 97% Rt 1.155 min; LCMS: m/z, M+, 202.8.
Workup
- temperaturemaintaining the reaction temperature between −5° C. and 0° C
- temperaturemaintaining the reaction temperature between −5° C. and 0° C. (Note
- additionThe diazotized mixture should be also kept at −5° C. through out the addition)
- additionAs the addition proceeds
- customa white solid precipitates
- additionWhen the addition
- filtrationThe precipitate is collected by filtration
- washwashed with cold water
- customdried under vacuum
Sources & evidence
- ORD record
- ord-5cdb54a342e548f1abc315fbc3be0fdf
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08071597B2
Linked notes
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