Hydrochloric Acid → HCID 68653086, compound
Reaction equation
[C@H:1]12[CH2:9][C@H:5]([O:6][C:7]1=[O:8])[CH2:4][O:3][CH2:2]2.[OH-:10].[Na+].Cl>CO>[OH:10][C@H:5]1[CH2:4][O:3][CH2:2][C@@H:1]([C:7]([OH:6])=[O:8])[CH2:9]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 25.5 mmol of (cis)-3,6-dioxabicyclo[3.2.1]-octan-7-one in 500 ml of methanol is adjusted to pH 9 with 0.1M NaOH. The solution is stirred at constant pH until conversion is complete, and is adjusted to pH 6.5 with 0.1 M HCl before the methanol is evaporated off. The title compound is identified from the aqueous solution by means of the Rf by ion exchange chromatography (Amberlite XAD-2 resin).
Workup
- customis evaporated off
Sources & evidence
- ORD record
- ord-6846b9d460454783aa94abde192b63ed
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08071651B2
Reaction notes
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