Hydroxyamine hydrochloride → N-[(1-methylpyrrol-2-yl)methylidene]hydroxylamine
Reaction equation
[CH3:1][C:2]1C=[CH:5][NH:4][C:3]=1C=O.Cl.[NH2:10][OH:11].[C:12]([O-])(=O)[CH3:13].[Na+]>CO>[CH3:5][N:4]1[CH:3]=[CH:2][CH:1]=[C:12]1[CH:13]=[N:10][OH:11]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Methyl-2-pyrrolecarboxaldehyde (5 g), hydroxylamine hydrochloride (9.55 g) and sodium acetate (11.28 g) were dissolved in methanol (100 ml) and the solution was refluxed for 12 hours. Aftre confirming the completion of the reaction using TLC, the resulting mixture was purified by column-chromatography (ethyl acetate/hexane=3/1) to yield the compound (5.01 g, 88%) as a brown solid.
Workup
- temperaturethe solution was refluxed for 12 hours
- customthe resulting mixture was purified by column-chromatography (ethyl acetate/hexane=3/1)
Sources & evidence
- ORD record
- ord-c08aeab8ff784df5a663ac98b5911cdf
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08071650B2
Reaction notes
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