Dichloromethane → (3S)-piperidine-3-carboxylic acid hydrochloride
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([C:14]([OH:16])=[O:15])[CH2:9]1)=O)(C)(C)C.C(Cl)[Cl:18]>Cl.O1CCOCC1>[ClH:18].[NH:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([C:14]([OH:16])=[O:15])[CH2:9]1Participants
5
Procedure
A mixture of (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (4.0 g, 0.017 mol) in methylene chloride (10 mL, 0.2 mol) and 4.0 M of hydrogen chloride in 1,4-dioxane (30 mL) was stirred at rt for 2 hours. The volatiles were removed in vacuo to afford the desired product in quantitative yield. The crude product was used in the following step without further purification. LCMS: m/z 166.2 (M+H)+.
Workup
- customThe volatiles were removed in vacuo
Sources & evidence
- ORD record
- ord-08d1610d100f426a97702e12944ff41e
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08071624B2
Reaction notes
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