Hydrochloric Acid → (3-Benzyloxy-4-chloro-phenyl)-acetic acid ethyl ester
Reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:16][C:17]([OH:19])=[O:18])[CH:12]=[CH:13][C:14]=1[Cl:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:21][CH2:22]O>>[CH2:21]([O:18][C:17](=[O:19])[CH2:16][C:11]1[CH:12]=[CH:13][C:14]([Cl:15])=[C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:10]=1)[CH3:22]Participants
4
Procedure
(3-Benzyloxy-4-chloro-phenyl)-acetic acid (8 g) was treated with hydrogen chloride (4N in 1,4-dioxane; 6 mL) in EtOH (100 mL) at 80° C. for 3 hours. After concentrating to dryness, the residue was purified by silica gel chromatography to give (3-benzyloxy-4-chloro-phenyl)-acetic acid ethyl ester.
Workup
- concentrationAfter concentrating to dryness
- customthe residue was purified by silica gel chromatography