Pyrrolidine → 5-Nitro-2-pyrrolidin-1-yl-pyrimidine

HRID 657253

Reaction equation

Cl[C:2]1[N:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>>[N+:8]([C:5]1[CH:4]=[N:3][C:2]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:7][CH:6]=1)([O-:10])=[O:9]

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 825442-Chloro-5-nitropyrimidine

Product 1

HCID 587706385-Nitro-2-pyrrolidin-1-yl-pyrimidine

Procedure

Prepared essentially as described in Example 69a, using 2-chloro-5-nitro-pyrimidine and pyrrolidine. 1H NMR (DMSO-d6) δ 9.11 (s, 2H), 3.62 (m, 4H), 1.97 (m, 4H).

Workup

customPrepared essentially

Sources & evidence

ORD record: ord-6e1f95824d2c43d08e815127e2bf7f25
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08071768B2

Linked notes

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