Adipic Acid → HCID 178484387, compound
Reaction equation
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:10]([OH:19])(=[O:18])[CH2:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16].C(OCC)(=O)C>CO>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:10]([O-:19])(=[O:18])[CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O-:17])=[O:16]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
10.00 g of the metformin free-base and 4.411 g of adipic acid were stirred in 150 ml of methyl alcohol at 40° C., and then ethyl acetate was added thereto. The produced crystal was filtered and dried in hot air, thus obtaining 12.06 g (yield: 98.9%) of metformin adipate.
Workup
- filtrationThe produced crystal was filtered
- customdried in hot air
Sources & evidence
- ORD record
- ord-77f55f0e945b4a69a64eac2d9498f297
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08076377B2
Reaction notes
Loading…