Cyclohexylamine → 1-Cyclohexyl-3-methylurea
Reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[CH:5]1([NH2:11])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1>C(OCC)C>[CH3:1][NH:2][C:3]([NH:11][CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In 500 ml of ethyl ether is dissolved 57 g of methyl isocyanate and, then, 99 g of cyclohexylamine is added dropwise, whereupon crystals separate. The crystals are washed with ether. By the above procedure is obtained 105 g of N-methyl-N'-cyclohexylurea. melting point: 160°-161° C.
Workup
- customseparate
- washThe crystals are washed with ether
Sources & evidence
- ORD record
- ord-764e2897aceb41659d0eff4f06787120
- Source dataset
- uspto-grants-1978_12
- Patent number
- US04129654
Reaction notes
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